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Sen. Trent Lott (R-MS) resigns as the Senate's Republican leader following a two-week ordeal over racially divisive remarks. Senators are planning a conference call Monday to select Bill Frist (R-TN) to succeed Lott. Hear NPR's David Welna, NPR's Julie Rovner, NPR's Lynn Neary and Sen. Arlen Specter (R-PA).

Morning Edition presents its first original radio play, I'd Rather Eat Pants, written by Peter Ackerman and produced by L.A. Theatre Works. The five-act play, starring Edward Asner and Anne Meara, is a comic tale of an elderly couple's cross-country trek on a young slacker's motorcycle. They're in search of fame, fortune and a whole lot more. NPR's Bob Edwards and Susan Stamberg have cameo roles. Part four of Morning Edition's five-part original radio drama I'd Rather Eat Pants.

Puzzle master Will Shortz quizzes one of our listeners, and has a challenge for everyone at home. (This week's winner is Barbara Szelag from Tampa, Florida. She listens to Weekend Edition on member station WUSF in Tampa.)

A Weekend Edition series continues: What are the best albums that have never made it to CD? Hear from Village Voice and Jazz Times writer Lara Pellegrinelli (left), musician and co-owner of Amoeba Records Joe Goldmark, and Bill Monroe, author of the book Country Music, U.S.A. Pellegrinelli picks Embers and Ashes by Shirley Horn; Goldmark likes Clover, by the group of the same name. Monroe's choice is The Blue Sky Boys. Hear samples of "I Thought About You," "Santa Fe" and "Asleep in the Briny Deep."

Michele Norris and Lynn Neary read some of the letters received at All Things Considered this week.

Peter Moore, London Town Crier, is leaving his post and is searching for someone to replace him. He also leads a big parade on New Year's Day. Hear NPR's Scott Simon.

The Web site TomPaine.com has offered a $10,000 reward to whoever can prove the identity of what the site is calling "The Eli Lilly Bandit." Someone inserted two paragraphs into the Homeland Security Bill protecting drug manufacturer Eli Lilly from lawsuits by parents who claim the company's vaccines caused their children's autism. Major suspects include Sen. Bill Frist, Rep. Dick Armey and the White House. NPR's Alex Chadwick investigates the mystery.

Nearly a century ago, explorer Hanns Vischer undertook a grueling 1,500-mile journey by camel across the Sahara desert. He later said that he entered the desert like a fool, and left it nearly crushed. A modern-day explorer has recreated his trek.

Six days a week, Beth Simon rides the city buses in her Pennsylvania city. If they ran on Sundays, she would ride them then, too. Beth Simon is 42 and has mental retardation. She's not trying to get anywhere on the buses; she's turned them into a community. NPR's Joseph Shapiro reports.

Dr. Seuss' Grinch was a mean one. He hated Christmas so much that he decided to steal it --presents, the Whos' feast, tree and all. NPR's Elizabeth Blair reports on the grumpiest holiday character since Scrooge as part of the Present at the Creation series.