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On the 25th anniversary of John Lennon's death, we listen to his introspective song, "In My Life," which was released in 1965. The former Beatle and peace activist John Lennon was murdered outside his New York City apartment at age 40 on Dec. 8, 1980.

Even as a child, Benjamin Carson wanted to be a doctor. Now a renowned pediatric neurosurgeon, Carson believes he owes his success to his mother, a domestic who received only a third-grade education.

The International Atomic Energy Agency and its chief, Mohamed ElBaradei, receive the 2005 Nobel Peace Prize. Matthew Bunn, acting executive director of the Project on Managing the Atom at Harvard University's John F. Kennedy School of Government, discusses the U.N. watchdog group and its work.

New York City is increasing security on its subways after receiving what Mayor Mike Bloomberg calls a specific threat to mass transit in the coming days. At a press conference Thursday, he made note of an unusual "level of specificity" and said the threat originated overseas.

NPR's Puzzlemaster Will Shortz quizzes one of our listeners, and has a challenge for everyone at home. (This week's winner is Larry Davis from Santa Monica, California. He listens to Weekend Edition on member station KCRW.)

Scott Simon talks to Matt Shardlow of UK conservation group Buglife about the decline in flying invertebrates in the UK and how that could spell environmental disaster.

Los Angeles Mayor Antonio Villaraigosa is leading a task force on poverty for the U.S. Conference of Mayors. He tells Michele Norris about his plan to fight poverty, homelessness and other issues facing his city and others around the nation.

Federal Emergency Management Agency Director Mike Brown, barraged by criticism for the government's response to Hurricane Katrina, will no longer lead the relief effort on Gulf Coast and instead will work on "big picture" issues in Washington, D.C.

During the opening day of the Enron fraud and conspiracy trial, federal prosecutors present their case against former executives Kenneth Lay and Jeffrey Skilling. Defense lawyers also give their opening statements. The energy giant collapsed in 2001 -- the largest bankruptcy in U.S. history at the time.

President Bush delivers his fifth State of the Union address Tuesday night. The president is expected to talk about ways to reduce U.S. dependence on foreign oil, and control rising health care costs. Other key topics will include the war in Iraq, Iran's nuclear program and last week's Palestinian elections.